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What Are Lipid Nanoparticles (LNPs)?
Lipid nanoparticles (LNPs) are nano-sized capsules, approximately 100 nm in diameter, that are made of lipids.
LNPs encapsulate nucleic acids such as mRNA and siRNA and efficiently deliver them into cells upon contact. This property is expected to enable applications in fields such as gene therapy.
Toshiba's LNP Technology
Toshiba's LNP technology is characterized by biodegradability and targeting ability.
LNPs developed by Toshiba use proprietary biodegradable lipids as their main component. These LNPs biodegrade within cells and efficiently deliver nucleic acids.
In addition, the targeting properties of Toshiba's LNPs means that the amount and timing of delivery can be varied depending on the type of cell they contact.
![[Image] Toshiba's LNP Technology](/content/toshiba/ww/products-solutions/lnp/_jcr_content/root/contentsArea/mainarea/layoutcontainer_1237/image.coreimg.png/1749541387774/lnp-1.png)
Targeted Delivery Properties of Toshiba's LNPs
Toshiba's LNPs exhibit different delivery characteristics depending on the type of target cell. These characteristics are determined by the design of the lipid components, allowing LNPs to be tailored with the appropriate lipid composition to match the intended recipient cells.
For example, cancer-targeting LNPs deliver genes at a higher rate to cancer cells (breast cancer cells) than to normal cells (normal mammary gland cells). In the image on the right, a gene expressing green fluorescent protein (GFP mRNA) is delivered in greater amounts to the cancer cells, causing them to glow green.
Rapid Optimization and Design Using AI
Toshiba's AI technology is used in the design of targeted LNPs. Digital information is used to design optimal LNPs, enabling rapid design of LNPs tailored to specific needs.
A large number of LNPs with different lipid compositions can be grouped using Toshiba’s proprietary AI model (see image on right).
Based on the analysis results, the appropriate LNP composition can be inferred according to the intended application.
![[Image] Rapid Optimization and Design Using AI](/content/toshiba/ww/products-solutions/lnp/_jcr_content/root/contentsArea/mainarea/layoutcontainer_1237_652376512/image.coreimg.png/1749541316734/lnp-4.png)
Related Information
Journal
RUNX1 Inhibition Using Lipid Nanoparticle-Mediated Silencing RNA Delivery as an Effective Treatment for Acute Leukemias
掲載誌等 Experimental Hematology Volumes 112–113
https://www.sciencedirect.com/science/article/
abs/pii/S0301472X22002569
RUNX1 Inhibition Using Lipid Nanoparticle-Mediated Silencing RNA Delivery as an Effective Treatment for Acute Leukemias
Experimental Hematology Volumes 112–113
https://www.sciencedirect.com/science/article/abs/pii/S0301472X22002569
Non-viral inducible caspase 9 mRNA delivery using lipid nanoparticles against breast cancer: An in vitro study
Biochemical and Biophysical Research Communications（2022） Volume 635
https://www.sciencedirect.com/science/article/abs/pii/S0006291X22013675
Non-viral inducible caspase 9 mRNA delivery using lipid nanoparticles against breast cancer: An in vitro study
掲載誌等 Biochemical and Biophysical Research Communications（2022） Volume 635
https://www.sciencedirect.com/science/article/
abs/pii/S0006291X22013675
Journal of Nanomedicine ISSN: 2578-8760
International Conference
RUNX1 Inhibition Using Lipid Nanoparticle-Mediated Silencing RNA Delivery as an Effective Treatment for Acute Leukemias
掲載誌等 Experimental Hematology Volumes 112–113
https://www.sciencedirect.com/science/article/
abs/pii/S0301472X22002569
Non-viral inducible caspase 9 mRNA delivery using lipid nanoparticles against breast cancer: An in vitro study
掲載誌等 Biochemical and Biophysical Research Communications（2022） Volume 635
https://www.sciencedirect.com/science/article/
abs/pii/S0006291X22013675
Shoji SAITOH et.al. (2025) mRNA-LNP Vaccine Providing Antigen and Co-Stimulation in the Tumor Microenvironment (CART-Vac) Enhances CAR-T Cell Function, Annual meeting of the American Society of Gene & Cell Therapy (ASGCT2025)
Shoji SAITOH et.al. (2021) Non-viral delivery of therapeutic mRNA using tumor-tropic liposomes for solid tumors , Annual meeting of the American Society of Gene & Cell Therapy (ASGCT2021)
Shoji SAITOH et.al. (2020) Tumor-tropic liposome-mediated therapeutic delivery of mRNA for T cell malignancies, Annual meeting of the American Society of Gene & Cell Therapy (ASGCT2020)
